Pasadena, CA, USA. Neuroscientists discovered a novel response to human faces: neurons respond strongly when a patient sees an entire face, but much less to a face in which only a very small region has been erased.

The response is a critical tool for social interactions between humans. Without the ability to read faces and their expressions, it would be hard to tell friends from strangers upon first glance, let alone a sad person from a happy one.


The findings of researchers from the California Institute of Technology (Caltech), with the help of collaborators at Huntington Memorial Hospital (Pasadena) and Cedars-Sinai Medical Center (Los Angeles), appear in the journal Current Biology. "The finding really surprised us," says Ueli Rutishauser, first author on the paper, a former postdoctoral fellow at Caltech, and now a visitor in the Division of Biology. "Here you have neurons that respond well to seeing pictures of whole faces, but when you show them only parts of faces, they actually respond less and less the more of the face you show. That just seems counterintuitive."


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Whole and Partial Faces

This figure shows the kind of stimuli used in the study: whole faces (left) and only partly revealed faces.

The surprising finding was that although neurons respond most strongly to seeing the whole face, they actually respond much less to the middle panel than to the far right panel, even though the middle panel is more similar to the whole face.

Images courtesy of Ralph Adolphs, California Institute of Technology (Caltech).The team looked at recordings from the brain cells in neurosurgical patients, focusing on neurons located in the amygdala region of the brain, which has long been known to be important for the processing of emotions. However, the study results strengthen a growing belief among researchers that the amygdala has also a more general role in the processing of, and learning about, social stimuli such as faces.

Other researchers have described the amygdala's neuronal response to faces before, but this dramatic selectivity — which requires the face to be whole in order to elicit a response — is a new insight. "Our interpretation of this initially puzzling effect is that the brain cares about representing the entire face, and needs to be highly sensitive to anything wrong with the face, like a part missing," explains Ralph Adolphs, senior author on the study and Bren Professor of Psychology and Neuroscience and professor of biology at Caltech.

"This is probably an important mechanism to ensure that we do not mistake one person for another and to help us keep track of many individuals." The team recorded brain-cell responses in human participants who were awaiting surgery for drug-resistant epileptic seizures.

As part of the preparation for surgery, the patients had electrodes implanted in their medial temporal lobes, the area of the brain where the amygdala is located. By using special clinical electrodes that have very small wires inserted, the researchers were able to observe the firings of individual neurons as participants looked at images of whole faces and partially revealed faces. The voluntary participants provided the researchers with a unique and very rare opportunity to measure responses from single neurons through the implanted depth electrodes, says Rutishauser.

"This is really a dream collaboration for basic research scientists," he says. "At Caltech, we are very fortunate to have several nearby hospitals at which the neurosurgeons are interested in such collaborative medical research."

The team plans to continue their studies by looking at how the same neurons respond to emotional stimuli. This future work, combined with the present study results, could be highly valuable for understanding a variety of psychiatric diseases in which this region of the brain is thought to function abnormally, such as mood disorders and autism.

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