Seattle, WA, USA. Investigations into human neurology have been enriched by mouse and rat brain atlases. They support experimentation and enable direct comparisons with other organisms, especially humans.

The more traditional brain atlases have limits — they offer an incomplete map of the brain and its function. A new atlas is the first to augment traditional and well-understood brain mapping methods with gene expression data to help delineate brain structures.


The result is a high-resolution vector-based digital mouse brain atlas, The Allen Reference Atlas, which is designed specifically for web applications. It is considered an essential companion to the Allen Brain Atlas. An online gene expression database, it is an open access resource generated by The Allen Institute for Brain Science

The volume is a standard, full-colour, high-resolution brain atlas of C57BL/6J male mouse whose extensive images are enhanced by a hierarchically organized taxonomy of mouse brain structure.

• Full-color plates show the most frequently annotated coronal and sagittal brain sections in fine anatomical detail.
  
  
• Molecular markers distinctly captured in the online atlas database refine the delineation of brain structures, thereby lending increased accuracy to the reference atlas.
  
  
• High image resolution;
  
  
• Every brain structure is assigned a distinct color based on its hierarchical position in the brain. This color scheme provides the best visual effect to emphasize brain organization and greatly facilitates informatics processing while facilitating unique definition and segmentation.
  
  
• More than 80 genes showing unique expression patterns in the brain are included as markers to substantially increase the accuracy of brain structure delineations.

Both the print/CD-ROM edition and the DVD-ROM edition offer seamless coverage with the interactive online version and the Allen Brain Atlas gene expression database, currently accessible online.

• The print edition is offered with a free accompanying CD-ROM featuring black and white versions of artwork in low-resolution PDF files for ease of reference.
  
  
• A separately published DVD-ROM edition contains all of the content from the printed version and its accompanying CD-ROM, as well as higher-resolution color versions of each anatomical plate in the printed book and 264 supplementary coronal images.

This atlas offers the unique opportunity to unite classical neuroanatomy with modern genomic science. It is thus a valuable resource for advancing the understanding of human brain disorders and diseases, such as Alzheimer’s, Parkinson’s, epilepsy, schizophrenia, autism, and addiction.

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