Shanghai, China. Genetic activity levels in the human brain during development might be caused by a handful of key regulatory molecules called microRNAs, which could explain how human cognitive abilities evolved in less than six million years.

A new study shows that genetic changes were substantial when compared to chimpanzees and macaques.


Scientists in China and Germany published their findings in the journal PLoS Biology. The authors studied gene activity in human, chimpanzee and macaque brains across their lifetimes. Starting from newborns, they investigated two brain regions: the cerebellum (responsible for motor activity) and the prefrontal cortex (which has roles in more complex behavior such as social interactions or abstract thinking.



Mehmet Somel, the lead author of the study, is with the Max-Planck-Institute for Evolutionary Anthropology.

Somel currently is doing work at the Center for Theoretical Evolutionary Genomics at the University of California, Berkeley.



Philipp Khaitovich, PhD, the senior author of the study, was formerly a Principal Investigator at the Max-Planck-Institute for Evolutionary Anthropology.

Khaitovich currently is a group leader at the CAS-MPG Partner Institute for Computational Biology (PICB).The science team first studied the simple gene activity differences between species that are seen at all ages. Although many genes show such simple differences, there was no disparity in numbers of these differences between the human and the chimpanzee evolutionary lineages. Moreover, most of these differences were observed in both of the brain regions studied, and the genes involved are not thought to be specifically involved in brain function. In the opinion of Mehmet Somel, the lead author of the study, these differences represent evolutionary "white noise" and have little importance for human brain evolution.

The team then looked for changes in gene activity during development, comparing the activity of genes in newborns and adults. In general, brain developmental patterns tend to be quite similar in humans, other primate species, and even mice. Nevertheless:

• The authors found that for hundreds of genes, humans display unique developmental patterns, with profiles that were different in shape and/or timing from those found in chimpanzees and macaques.
  
  
• Such human-specific developmental gene activity patterns were particularly widespread in the prefrontal cortex, where genes showing human-specific changes outnumbered genes showing chimpanzee-specific changes by four-fold.
  
  
• Developmental patterns in the cerebellum, by contrast, were much less human-specific.
  
  
• Furthermore, many genes displaying these human-specific patterns in the prefrontal cortex were known to have specific neural functions, implying roles in human cognitive development.

Looking for possible causes of this widespread developmental remodeling in the human prefrontal cortex, the authors stumbled upon an unexpected signal. Developmental patterns of genes that encode microRNAs (tiny but powerful regulators that target many other genes and processes) showed an even greater excess of human-specific changes in the prefrontal cortex than did comparable developmental patterns in ordinary genes.

Several of these changes in microRNA activity could be directly linked to human-specific changes in activity of their target genes. Since each microRNA may regulate the activity of hundreds of other genes, this finding provides a possible explanation to how hundreds of genes changed their activity patterns (in a coordinated way) during human brain development.

This result further implies that the evolution of human cognitive abilities might be traced back to a small number of mutations in key developmental regulators. Philipp Khaitovich, the senior author of the study, suggests that "identifying the exact genetic changes that made us think and act like humans might be easier than we previously imagined".

This said, it is likely to require much more work with a focus on the dynamics of brain development and wider use of transgenic mice, and even primate models.

Additionally, the authors point out that identification of the key human-specific DNA mutations could help us to determine how close the Neanderthals' cognitive abilities were to ours. "If Neanderthals' brain development was similar to that of chimpanzees and macaques, it would be no wonder that they became extinct when confronted by Modern Humans," says Mehmet Somel.

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